Ayesha Kiran Mendes Jun 2026

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Under elevated temperatures (42°C for one hour), these chaperones swiftly translocate to the outer mitochondrial membrane (OMM). Investigating Distal Neuropathy

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Defining the exact, day-to-day role that HSPBs play when interacting with the outer mitochondrial membrane. ayesha kiran mendes

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Following heat shock or intense cellular stress, they rapidly shift to the outer mitochondrial membrane (OMM).

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Her work indicates that the Pro182Leu mutant causes an abnormal enrichment of HSPB1 on the outer mitochondrial membrane even under normal basal conditions. This mistargeting triggers a harmful, underlying cell-signaling pathway that leads directly to mitochondrial dysfunction and the degeneration of motor neurons. Collaborative Ecosystem and Scientific Impact Under elevated temperatures (42°C for one hour), these

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Ayesha Kiran Mendes has contributed to high-impact research in biological and clinical sciences. A significant recent paper includes:

"State-dependent alterations in circulating mitochondrial DNA copy number and common deletion in bipolar disorder" : Published in Molecular and Cellular Neuroscience

, which is known to cause peripheral neuropathy. Her research found that this mutant version of the protein stays enriched on the OMM even under basal (non-stress) conditions, leading to mitochondrial dysfunction through unknown signaling pathways. Universiteit Antwerpen Academic Background Current Position : FWO PhD Fellow (Research Foundation - Flanders) at the University of Antwerp , affiliated with the Peripheral Neuropathies Group MSc in Neurosciences : Obtained through the prestigious Erasmus Mundus (Neurasmus) program Undergraduate : Biomedical Sciences. LinkedIn Belgium or her work with the Peripheral Neuropathies Group Ayesha Kiran Mendes - University of Antwerp | LinkedIn